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• Describe multiple categories of Extrapyramidal Side Effects (EPSE) and specific medications implicated
• Differentiate between Serotonin Syndrome and Neuroleptic Malignant Syndrome
• Recognize Stevens-Johnson Syndrome and the medications implicated
• Explain the significance of hyponatremia and the Syndrome of Inappropriate Antidiuretic Hormone (SIADH) as it relates to medication and polypharmacy
• Recall updated evidence for FDA Black Box Warning (BBW) of medication induced suicidality
• Identify FDA Black Box Warning (BBW) of medication and QTc prolongation in all populations, with a focus on geriatric patients

A. Pharmacokinetics
B. Extrapyramidal Side Effects (EPSE)
  1. Categories
  2. Treatment
  3. High-risk categories
C. Serotonin Syndrome (SS)
  1. Medications implicated
  2. Symptoms
  3. Course
  4. Treatment
D. Neuroleptic Malignant Syndrome (NMS)
  1. Medications implicated
  2. Symptoms
  3. Course
  4. Treatment
  5. Case Study
E. Steven Johnson’s Syndrome (SJS)
  1. Medications implicated
  2. Symptoms
  3. Course
  4. Treatment
F. Hyponatremia and Syndrome of Inappropriate Antidiuretic Hormone (SIADH)
  1. Symptoms
  2. Course
  3. Medications implicated
G. Black Box Warning and Suicidality
  1. Definition
  2. Medications implicated
  3. Current theories
H. Black Box Warning and QTc Prolongation
  1. Definition
  2. Medications implicated
I. Risk Evaluation and Mitigation Strategies (REMS)
  1.Definition
  2. Practice Implications

• Nurse Practitioners
• Nurses
• Psychiatrists
• Psychologists
• Counselors
• Alcoholism and Drug Abuse Counselors
• Social Workers
• Marriage and Family Therapists
• Psychiatric Nurse Practitioners
• Case Managers